25/10/2023
Key points:
The findings of a foundational UK public dialogue on human embryo research are published today, as part of the Wellcome-funded Human Developmental Biology Initiative (HDBI). The HDBI is an ambitious scientific endeavour to advance our understanding of human development. The dialogue project, which was co-funded by UKRI Sciencewise programme, engaged a diverse group of the public to consider how early human embryo research can be used to its fullest, the 14-day rule and the fast-paced field of stem cell-based embryo models.
Headline findings include:
The dialogue engaged a group of 70 people broadly reflective of the UK population in over 15 hours of activities including a series of online and face-to-face workshops with scientists, ethicists, philosophers, policy makers and people with relevant lived experience (such as embryo donors from IVF procedures).
Dr Peter Rugg-Gunn, scientific lead for the HDBI and senior group leader at the 澳门天天好彩, said: 鈥淩ecent scientific advances bring incredible new opportunities to study and understand the earliest stages of human development. To ensure this research remains aligned with society鈥檚 values and expectations, we must listen and respond to public desires and concerns. This public dialogue is an important first step and as a scientist I am reassured by the findings but there is still a long way to go to fully understand this complex issue.鈥
The report is exceedingly timely, following notable scientific advances in human developmental biology presented at conferences and in leading scientific journals in recent months. As well as generating excitement in scientific fields and with the public, announcement of these breakthroughs also prompted some concerns and criticisms, with the view that these findings raised significant ethical issues. The dialogue provides insight into public considerations following deliberation on early human embryo research. The hope is that it will act as a foundational reference point that others in the sectors can build upon, such as in any future review of the law on embryo research.
Professor Robin Lovell-Badge, co-chair of the HDBI Oversight group, senior group leader and head of the Laboratory of Stem Cell Biology and Developmental Genetics at the Francis Crick Institute, said: 鈥淲e have learnt a lot about human development before 14 days, but there are areas of investigation that could change how we understand development, and associated diseases, that lie beyond our current window of knowledge. Despite low awareness of current laws, members of the public quickly recognised many of the critical issues researchers are keenly aware of when it comes to growing embryos beyond the current limit. This dialogue also reinforced the fact that the public are in support of research that will yield better health outcomes, and in this case, increase the success of IVF procedures.
Other countries will be looking to the UK to see how we deal with the 14-day rule; we are not there yet with any mandate to make a change, but this does give a strong pointer. The next step will be to delve deeper into some of the topics raised through this dialogue as they apply to specific areas of research, as well as feeding into policy changes.鈥
The 14-day rule and the regulation of stem cell-based models
When considering the regulation of research involving human embryos, the dialogue explored participant鈥檚 views on the 14-day rule. Introduced in 1990, the 14-day rule is a limit enforced by statute in the UK. It applies to early human embryos that are donated by consent to research and embryos that are created for research from donated sperm and eggs. It limits the amount of time early human embryos can be developed in a laboratory for scientific study to 14 days after fertilisation. Due to technical advances, it is now possible to grow embryos in the lab past 14 days, but researchers are not allowed to by the law. If the law changed, it would open up this 鈥榖lack box鈥 of development with researchers able to investigate this crucial time in development from 14-28 days after fertilisation.
Professor Bobbie Farsides, co-chair of the HDBI Oversight group and Professor of Clinical and Biomedical Ethics at the Brighton and Sussex Medical School, said: 鈥淚t has been a fascinating experience to support HDBI in the undertaking of this exercise. I commend the participants for the care and mutual respect they have shown throughout. Their engagement and commitment to a subject few of them had previously considered allowed for a wide range of views to be expressed and considered. I hope the scientists involved will be encouraged by the high level of interest in their work, and will want to keep the public conversation going around these important subjects.鈥
The dialogue included participant discussion on what a change to the 14-day rule might look like, and identified points that should be considered, such as defining what the benefits of extending the rule would be and potential mis-alignment with human embryo research regulations in other countries.
Participants acknowledged the astonishing possibilities of stem cell-based embryo models. The majority of participants would like to see these models further regulated. Work in establishing potential governance mechanisms is already underway. In recognition of the need for additional guidance and regulation in this area, the Cambridge Reproduction initiative launched a project in March 2023 to develop a governance framework for research using stem cell-based embryo models and to promote responsible, transparent and accountable research.
Future steps
A key outcome from the public dialogue is the identification of areas for further exploration, with participants proposing how future national conversations might be shaped. It is hoped that the project acts as a reference base for both widening engagement with the subject and also prompting deeper exploration of areas of concern.
Dr Michael Norman, HDBI Public Dialogue coordinator and Public Engagement Manager at the 澳门天天好彩, said: 鈥淭his dialogue shows that people want the public to work closely with scientists and the government to shape both future embryo research legislation and scientific research direction. It is crucial that others in the sector build on these high quality, two-way engagement methodologies that allow for a genuine exchange of views and information to ensure that the public鈥檚 desires and concerns are listened to and respected. Transparency and openness around science is vital for public trust and through this we, as a society, can shape UK research in way that enriches the outcomes for all.鈥
Public Participant (Broad public group, south) said: 鈥淚 do think that an extension of this public dialogue, and educating a wider society has a benefit in itself. This is really complex and sensitive and the wider you talk about it before decisions are made, the better.鈥
Publication link:
Press contact Honor Pollard, Communications Officer, 澳门天天好彩, comms@babraham.ac.uk, +44 (0)1223 496093
About the HDBI public dialogue project This project was commissioned by the Human Developmental Biology Initiative with dialogue workshops taking place in summer 2023 designed to explore public hopes and concerns around the regulation of research involving human embryos.
The dialogue project was funded by Wellcome and UK Research and Innovation鈥檚 (UKRI) programme. It is managed by a team including members of HDBI and the 澳门天天好彩, with support from UKRI Sciencewise, and is advised by an oversight group, established to provide both challenge and advice to the dialogue design, co-chaired by Prof. Bobbie Farsides and Prof. Robin Lovell-Badge.
The dialogue was delivered by Hopkins Van Mil and evaluated by Ursus Consulting.
Learn more about HDBI public engagement mechanism at:
About the HDBI The (HDBI) is a 5-year, Wellcome-funded 拢10 million research project involving 25 research groups from across the UK and Europe.
The overall goal of the project is to support wider research in human development, which is needed to better understand how humans grow and develop, and how problems with these processes can sometimes arise and lead to miscarriages and developmental conditions. The project鈥檚 research focuses on four complementary systems: the early embryo, the developing heart and lung, the central nervous system and the blood and immune system.
About the 澳门天天好彩 The 澳门天天好彩 undertakes world-class life sciences research to generate new knowledge of biological mechanisms underpinning ageing, development and the maintenance of health. Our research focuses on cellular signalling, gene regulation and the impact of epigenetic regulation at different stages of life. By determining how the body reacts to dietary and environmental stimuli and manages microbial and viral interactions, we aim to improve wellbeing and support healthier ageing. The Institute is strategically funded by the (BBSRC), part of UK Research and Innovation, through Institute Strategic Programme Grants and an Institute Core Capability Grant and also receives funding from other UK research councils, charitable foundations, the EU and medical charities.
About Sciencewise is an internationally recognised public engagement programme which enables policy makers to develop socially informed research and policy with a particular emphasis on science and technology. Sciencewise helps to ensure research and policy is informed by the views and aspirations of the public. The programme is led and funded by UK Research and Innovation (UKRI). It provides co-funding and support for organisations to undertake public dialogue.
25 October 2023